A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
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Herpes simplex virus latency-associated transcript is a stable intronBovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting ApoptosisIdentification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT): translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT.Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycleA 2.9-kilobase noncoding nuclear RNA functions in the establishment of persistent Hz-1 viral infection.Identification of the pseudorabies virus promoter required for latency-associated transcript gene expression in the natural host.Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.A mutation in the latency-related gene of bovine herpesvirus 1 disrupts the latency reactivation cycle in calves.Herpes simplex virus type 1 and bovine herpesvirus 1 latency.The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanismExperimental investigation of herpes simplex virus latencyThe region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation.The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript.A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-base-pair region located between the promoter and the 5' end of the 2.0 kilobase latency-associated transcriptThe abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia.Selection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcriptA 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbitsExpression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigsHerpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia.Analysis of a herpes simplex virus type 1 LAT mutant with a deletion between the putative promoter and the 5' end of the 2.0-kilobase transcript.The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latencyTwo open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latencyThe herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2.Induction of reactivation of herpes simplex virus in murine sensory ganglia in vivo by cadmium.Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts.An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1.The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic RabbitsActivity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript.A herpes simplex virus type 1 mutant lacking the ICP0 introns reactivates with normal efficiencyReactivation of HSV-1 following explant of tree shrew brain.Impairment in reactivation of a latency associated transcript (LAT)-deficient HSV-2 is not solely dependent on the latent viral load or the number of CD8(+) T cells infiltrating the ganglia.Construction of a herpes simplex virus type 1 mutant with only a three-nucleotide change in the branchpoint region of the latency-associated transcript (LAT) and the stability of its two-kilobase LAT intron.Complexity of Interferon-γ Interactions with HSV-1.Human corneal cells and other fibroblasts can stimulate the appearance of herpes simplex virus from quiescently infected PC12 cells.Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell lineHerpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro.Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.Relaxed repression of herpes simplex virus type 1 genomes in Murine trigeminal neurons
P2860
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P2860
A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
A herpes simplex virus type 1 ...... inetics from latent infection.
@ast
A herpes simplex virus type 1 ...... inetics from latent infection.
@en
type
label
A herpes simplex virus type 1 ...... inetics from latent infection.
@ast
A herpes simplex virus type 1 ...... inetics from latent infection.
@en
prefLabel
A herpes simplex virus type 1 ...... inetics from latent infection.
@ast
A herpes simplex virus type 1 ...... inetics from latent infection.
@en
P2093
P2860
P1433
P1476
A herpes simplex virus type 1 ...... inetics from latent infection.
@en
P2093
J G Spivack
M T McIntosh
N W Fraser
R P Lirette
S Deshmane
P2860
P304
P407
P577
1990-07-01T00:00:00Z