Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain.
about
A functional analysis of the spacer of V(D)J recombination signal sequencesAnalysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpointsConservation of sequence in recombination signal sequence spacersTargets of somatic hypermutation within immunoglobulin light chain genes in zebrafish.Diversity of immunoglobulin lambda light chain gene usage over developmental stages in the horseEnumeration and characterization of DJH structures in mouse fetal liver.Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors.Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappaB cell development in mice that lack one or both immunoglobulin kappa light chain genes.Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in transPyIgClassify: a database of antibody CDR structural classifications.Regulating antigen-receptor gene assembly.Level of human TCRBV3S1 (V beta 3) expression correlates with allelic polymorphism in the spacer region of the recombination signal sequence.Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangementAutoreactive B cells in the marginal zone that express dual receptorsProspective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling.Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements.Genetic modulation of T cell receptor gene segment usage during somatic recombination.Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern.Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivoUnexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice.Inversions produced during V(D)J rearrangement at IgH, the immunoglobulin heavy-chain locus.Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development.Allelic exclusion of immunoglobulin genes: models and mechanisms.Nucleotide deletion and P addition in V(D)J recombination: a determinant role of the coding-end sequence.Environmental and genetic factors shape the human T-cell receptor repertoire.Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production.kappa+lambda+ dual receptor B cells are present in the human peripheral repertoireRegulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes.Phenotyping of autoreactive B cells with labeled nucleosomes in 56R transgenic mice.The primary antibody repertoire of kappa-deficient mice is characterized by non-stochastic Vlamda1 + V(H) gene family pairings and a higher degree of self-reactivity.A human immunoglobulin lambda locus is similarly well expressed in mice and humans.The cleavage efficiency of the human immunoglobulin heavy chain VH elements by the RAG complex: implications for the immune repertoire.
P2860
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P2860
Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mouse kappa light-chain recomb ...... o those of lambda light chain.
@en
Mouse kappa light-chain recomb ...... o those of lambda light chain.
@nl
type
label
Mouse kappa light-chain recomb ...... o those of lambda light chain.
@en
Mouse kappa light-chain recomb ...... o those of lambda light chain.
@nl
prefLabel
Mouse kappa light-chain recomb ...... o those of lambda light chain.
@en
Mouse kappa light-chain recomb ...... o those of lambda light chain.
@nl
P2860
P356
P1476
Mouse kappa light-chain recomb ...... o those of lambda light chain.
@en
P2093
P2860
P304
10721-10725
P356
10.1073/PNAS.88.23.10721
P407
P577
1991-12-01T00:00:00Z