Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.
about
SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repairPromotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy geneMicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocationDNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution patternMutation of POLB causes lupus in miceM17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in micemicroRNA-155 regulates the generation of immunoglobulin class-switched plasma cellsIntegrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceThe Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA contextAnalysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locusCells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.Elucidation of IgH intronic enhancer functions via germ-line deletionUracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutationIncorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivoNegative regulation of activation-induced cytidine deaminase in B cellsDisruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting.Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.Critical roles of chemokine receptor CCR10 in regulating memory IgA responses in intestines.Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.Parp3 negatively regulates immunoglobulin class switch recombination.HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligaseDoes DNA repair occur during somatic hypermutation?A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modificationH2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutationAlkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombinationATM is required for efficient recombination between immunoglobulin switch regions.The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regionsEAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity.UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.Regulation of class switch recombination and somatic mutation by AID phosphorylationPrimPol prevents APOBEC/AID family mediated DNA mutagenesisPol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1.
P2860
Q24541386-416F2A15-D826-47B6-881B-8180D484175DQ24617547-E9D9F56A-BBB5-4799-8E0A-EB8581391399Q24646923-612AB0A5-31DD-4829-A06B-E69B9C4F9AD5Q28506592-74E559B1-8DE1-4AAA-97E4-F9F0AD60F5E7Q28510640-79114546-E205-426E-8805-A71BE8C86A2DQ28513579-6DF56A46-6B98-48AD-94A2-E2C55CC6254BQ28589356-A7B64484-D18D-4B84-9D11-F5E2AC172308Q29619307-472F33AF-B5CE-46DF-97C6-670C9B769D82Q30857687-C967D6F0-B9AD-420B-8F2A-69BEC4698FE5Q30994273-EA48148D-BE8F-4CF0-B7EA-D52D75BA7340Q33741094-5E72ED50-9D49-49C8-8C9C-4CA4C43239B1Q33749938-DD11BC9C-7ABF-4446-813D-A8C2349DEC7EQ33886982-69F7064C-B14B-414D-B4A6-7750C8E1A019Q33952028-EBF571C7-E42C-4DE6-9EE7-8B612C616A99Q34063681-1F02EE71-B909-4B25-83A3-AC46CD712952Q34154230-FC70307A-92EA-44B7-BC85-7009C821F2D2Q34401362-08ADE39B-8537-4804-B18A-6A4E140955AEQ34479651-69943124-114F-4DD0-820F-2F0DAD58C9A9Q34494007-6911A5EB-920F-4570-8831-7AE4D57F8BF8Q34572374-88AD8A49-E80F-430C-9671-B1233C720D6CQ34624550-72A1C080-BB5C-47BC-A5CF-26936ADA2EB4Q35144590-64678FA8-2447-465A-BD3A-5DE8DE176A9EQ35213438-AF9F8AC0-E78D-4987-9311-890D8F73B344Q35546730-25EA2C4F-2594-41B6-B15C-6CEB930A0DC2Q35585876-90508769-DD6D-4C26-B0B9-28A32023FE6CQ35637214-335A4FAB-2948-4AFB-85B2-CFEAD9BA2015Q36054241-B4C3C6DE-20FE-4086-9067-1A985A756B12Q36173864-18F622A4-116E-4DC7-938F-0EF9C010BEBAQ36211150-D8D1D809-40BC-4471-B8B0-1DE55E7CD8F8Q36229591-7563DEB9-DC96-43C4-888F-3D7742E02CE2Q36370913-CE95A0AC-8C19-4D3E-A5BC-8B70B6F8EFEDQ36376956-90F10A05-F75D-40EC-8A03-2E328620E236Q36399334-276F5D28-00F3-4698-B19B-21A6B7D514E5Q36403120-739DCE80-FD03-4D62-823D-4AFE7149E650Q36661580-F0A1D30C-28F8-4DBC-8289-F02CEF8B765AQ36727872-6DCCD899-A9D6-4CB7-A7D5-B0B31DD96543Q36946561-5316956E-14C7-4EDC-A8AD-74B09010C72CQ36959012-E3F466D8-A0A5-476F-A758-7D36B3FD88E1Q37106800-A6EF11C4-C038-4A92-B7BE-29635FE1C3B2Q37240803-B8CD0E69-3A7B-4246-8DBB-7605B7E03112
P2860
Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Rapid methods for the analysis ...... sgenic and gene targeted mice.
@en
Rapid methods for the analysis ...... sgenic and gene targeted mice.
@nl
type
label
Rapid methods for the analysis ...... sgenic and gene targeted mice.
@en
Rapid methods for the analysis ...... sgenic and gene targeted mice.
@nl
prefLabel
Rapid methods for the analysis ...... sgenic and gene targeted mice.
@en
Rapid methods for the analysis ...... sgenic and gene targeted mice.
@nl
P2093
P2860
P356
P1476
Rapid methods for the analysis ...... sgenic and gene targeted mice.
@en
P2093
P2860
P304
P356
10.1093/NAR/25.10.1913
P407
P577
1997-05-01T00:00:00Z