Nuclear localization of p85s6k: functional requirement for entry into S phase.
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COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleusA novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translationS6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathwayDual requirement for a newly identified phosphorylation site in p70s6kUp-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's diseaseEthanol, Zn2+ and insulin interact as progression factors to enhance DNA synthesis synergistically in the presence of Ca2+ and other cell cycle initiators in fibroblastsNovel 5'TOPmRNAs regulated by ribosomal S6 kinase are important for cardiomyocyte development: S6 kinase suppression limits cardiac differentiation and promotes pluripotent cells toward a neural lineage.Regulated phosphorylation of 40S ribosomal protein S6 in root tips of maize.Structural and functional analysis of pp70S6k.Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis.Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.A heat-sensitive Arabidopsis thaliana kinase substitutes for human p70s6k function in vivo.Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylationOverexpressed genes/ESTs and characterization of distinct amplicons on 17q23 in breast cancer cells.Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPDPhospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation.A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene.Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway.Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinaseIKK-β mediates hydrogen peroxide induced cell death through p85 S6K1Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k.S6 kinase 2 potentiates interleukin-3-driven cell proliferationMorphoproteomic confirmation of a constitutively activated mTOR pathway in high grade prostatic intraepithelial neoplasia and prostate cancer.The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity.4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression.Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner.Phosphoinositide 3-kinase signaling in the vertebrate retina.Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation.Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation.Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains.The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.Immunolocalization of phospho-S6 kinases: a new way to detect mitosis in tissue sections and in cell culture.
P2860
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P2860
Nuclear localization of p85s6k: functional requirement for entry into S phase.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Nuclear localization of p85s6k: functional requirement for entry into S phase.
@en
type
label
Nuclear localization of p85s6k: functional requirement for entry into S phase.
@en
prefLabel
Nuclear localization of p85s6k: functional requirement for entry into S phase.
@en
P2093
P2860
P1433
P1476
Nuclear localization of p85s6k: functional requirement for entry into S phase
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1994.TB06418.X
P407
P577
1994-04-01T00:00:00Z