Conformational changes of P-glycoprotein by nucleotide binding.
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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycleStructural and functional asymmetry of the nucleotide-binding domains of P-glycoprotein investigated by attenuated total reflection Fourier transform infrared spectroscopyLigand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis.Secondary and tertiary structure changes of reconstituted LmrA induced by nucleotide binding or hydrolysis. A fourier transform attenuated total reflection infrared spectroscopy and tryptophan fluorescence quenching analysis.Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione.The multi-structural feature of the multidrug resistance gene product P-glycoprotein: implications for its mechanism of action (hypothesis).Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.Elevated and secreted phospholipase A₂ activities as new potential therapeutic targets in human epithelial ovarian cancer.Regulation of CFTR Cl- channel gating by ATP binding and hydrolysis.Maltose-binding protein is open in the catalytic transition state for ATP hydrolysis during maltose transport.Dissection of de novo membrane insertion activities of internal transmembrane segments of ATP-binding-cassette transporters: toward understanding topological rules for membrane assembly of polytopic membrane proteins.Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter.Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1).Allosteric modulation bypasses the requirement for ATP hydrolysis in regenerating low affinity transition state conformation of human P-glycoprotein.Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells.Proteolytic Cleavage of the Linker Region of the Human P-glycoprotein Modulates Its ATPase Function.Functional role of the linker region in purified human P-glycoprotein.The Q-loop disengages from the first intracellular loop during the catalytic cycle of the multidrug ABC transporter BmrA.Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding.Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1.The nucleotide-binding domains of P-glycoprotein. Functional symmetry in the isolated domain demonstrated by N-ethylmaleimide labelling.GSH inhibits trypsinization of the C-terminal half of human MRP1.Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis.Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility.Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein
P2860
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P2860
Conformational changes of P-glycoprotein by nucleotide binding.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Conformational changes of P-glycoprotein by nucleotide binding.
@en
type
label
Conformational changes of P-glycoprotein by nucleotide binding.
@en
prefLabel
Conformational changes of P-glycoprotein by nucleotide binding.
@en
P2093
P2860
P356
P1433
P1476
Conformational changes of P-glycoprotein by nucleotide binding.
@en
P2093
P2860
P304
P356
10.1042/BJ3280897
P407
P478
328 ( Pt 3)
P577
1997-12-01T00:00:00Z