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Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitroPurification and mechanism of human aldehyde oxidase expressed in Escherichia coliOptimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide PolymorphismsThe impact of single nucleotide polymorphisms on human aldehyde oxidaseAldehyde oxidase importance in vivo in xenobiotic metabolism: imidacloprid nitroreduction in mice.Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase.Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes.The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.Identification of hepatitis C virus inhibitors targeting different aspects of infection using a cell-based assaySmall-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release.Inhibition of xanthine oxidase by the aldehyde oxidase inhibitor raloxifene: implications for identifying molybdopterin nitrite reductasesInhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevanceInhibition of human liver aldehyde oxidase: implications for potential drug-drug interactions.A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite FormationThe mammalian aldehyde oxidase gene family.Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics.Predicting intrinsic clearance for drugs and drug candidates metabolized by aldehyde oxidase.Evaluation of rhesus monkey and guinea pig hepatic cytosol fractions as models for human aldehyde oxidase.Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndromeNicotinamide overload may play a role in the development of type 2 diabetesFavipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses.Inhibitory effects of flavonoids on molybdenum hydroxylases activity.Increasing recognition of the importance of aldehyde oxidase in drug development and discovery.Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.Aldehyde oxidase and its importance in novel drug discovery: present and future challenges.Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver.The role of drug metabolizing enzymes in clearance.Evaluation of the pharmacokinetics, safety and clinical efficacy of ziprasidone for the treatment of schizophrenia and bipolar disorder.An overview of aldehyde oxidase: an enzyme of emerging importance in novel drug discovery.Toward an Understanding of Structural Insights of Xanthine and Aldehyde Oxidases: An Overview of their Inhibitors and Role in Various Diseases.Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.Studies on the mechanism of aldehyde oxidase and xanthine oxidase.Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids.Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions.Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics.Plasma pharmacokinetics and metabolism of the antitumour drug candidate 2'-benzoyloxycinnamaldehyde in rats.Species differences in metabolism of ripasudil (K-115) are attributed to aldehyde oxidase.Effect of commonly used organic solvents on aldehyde oxidase-mediated vanillin, phthalazine and methotrexate oxidation in human, rat and mouse liver subcellular fractions.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Human liver aldehyde oxidase: inhibition by 239 drugs.
@ast
Human liver aldehyde oxidase: inhibition by 239 drugs.
@en
type
label
Human liver aldehyde oxidase: inhibition by 239 drugs.
@ast
Human liver aldehyde oxidase: inhibition by 239 drugs.
@en
prefLabel
Human liver aldehyde oxidase: inhibition by 239 drugs.
@ast
Human liver aldehyde oxidase: inhibition by 239 drugs.
@en
P2093
P2860
P356
P1476
Human liver aldehyde oxidase: inhibition by 239 drugs.
@en
P2093
Christine Beedham
Mary C Allen
Phuong Huynh
R Scott Obach
P2860
P356
10.1177/0091270003260336
P577
2004-01-01T00:00:00Z