Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.
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Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric DisordersA Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical CorrelatesMechanisms of granulin deficiency: lessons from cellular and animal modelsThe Evolution of the Secreted Regulatory Protein ProgranulinImmobilized metal affinity chromatography co-purifies TGF-β1 with histidine-tagged recombinant extracellular proteinsProgranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclastsAn ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicityProgranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.Progranulin regulates neuronal outgrowth independent of sortilinAdvances in understanding the molecular basis of frontotemporal dementia.Progranulin: an emerging target for FTLD therapies.Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers.MiR-130a regulates neurite outgrowth and dendritic spine density by targeting MeCP2Learning and memory with neuropathic pain: impact of old age and progranulin deficiency.Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Imbalance between TNFα and progranulin contributes to memory impairment and anxiety in sleep-deprived mice.Cellular effects of progranulin in health and disease.Human genetics as a tool to identify progranulin regulators.Structure, function, and mechanism of progranulin; the brain and beyond.Progranulin axis and recent developments in frontotemporal lobar degenerationProgranulin, lysosomal regulation and neurodegenerative disease.Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.Prosaposin is a regulator of progranulin levels and oligomerization.Progranulin regulates neurogenesis in the developing vertebrate retina.Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.Progranulin Deficiency Reduces CDK4/6/pRb Activation and Survival of Human Neuroblastoma SH-SY5Y Cells.Novel progranulin variants do not disrupt progranulin secretion and cleavage.Circulating progranulin as a biomarker for neurodegenerative diseasesProgranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling.Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration.Elevated progranulin contributes to synaptic and learning deficit due to loss of fragile X mental retardation protein.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation.Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes.Increased Wnt Signaling and Reduced Viability in a Neuronal Model of Progranulin-Deficient Frontotemporal Lobar Degeneration.Targeting microglia for the treatment of Alzheimer's Disease.
P2860
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P2860
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.
@en
type
label
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.
@en
prefLabel
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.
@en
P2093
P2860
P50
P1433
P1476
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.
@en
P2093
P2860
P2888
P304
P356
10.1007/S13238-010-0067-1
P577
2010-06-01T00:00:00Z