Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer.
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The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugsPIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signalingPim1 kinase synergizes with c-MYC to induce advanced prostate carcinomaCell-permeable Carboxyl-terminal p27Kip1 Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding ModesTargeting Pim kinases for cancer treatment: opportunities and challengesPIM1 kinase as a target for cancer therapyPim kinase inhibitors: a survey of the patent literatureConditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasiaA role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells.Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity.Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells.Trichomonosis, a common curable STI, and prostate carcinogenesis--a proposed molecular mechanism.Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair.PPemd26, an anthraquinone derivative, suppresses angiogenesis via inhibiting VEGFR2 signalling.Oncogenic activation in prostate cancer progression and metastasis: Molecular insights and future challenges.Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammationDifferential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma.The survival kinases Akt and Pim as potential pharmacological targets.Identification of quinones as novel PIM1 kinase inhibitorsPIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.Why target PIM1 for cancer diagnosis and treatment?Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.Regulation of prostate stromal fibroblasts by the PIM1 protein kinase.Discovery and identification of PIM-1 kinase inhibitors through a hybrid screening approach.Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancerSpectrum of T-lymphocyte activities regulating allergic lung inflammation.Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinasePim-1 plays a pivotal role in hypoxia-induced chemoresistance.The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells.Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1.miR-33a is a tumor suppressor microRNA that is decreased in prostate cancer.MYC and Prostate CancerPI3K-like kinases restrain Pim gene expression in endothelial cells.MicroRNA-486-5p targeting PIM-1 suppresses cell proliferation in breast cancer cells.
P2860
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P2860
Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer.
@en
Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer.
@nl
type
label
Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer.
@en
Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer.
@nl
prefLabel
Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer.
@en
Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer.
@nl
P2093
P356
P1433
P1476
Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer.
@en
P2093
Alexander Valdman
Peter Ekman
See-Tong Pang
Xiaolei Fang
P304
P356
10.1002/PROS.20064
P50
P577
2004-09-01T00:00:00Z