Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events.
about
The function of APC/CCdh1 in cell cycle and beyondCharacterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complexHuman BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APCEvidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2betap55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinaseCrystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpointTumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105Mitotic regulation of the human anaphase-promoting complex by phosphorylationInhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisonsDeterminants of conformational dimerization of Mad2 and its inhibition by p31cometCentromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome lossIdentification of a MAD2-binding protein, CMT2, and its role in mitosis.Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochoresSecurin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesisLesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiaeCheckpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complexMammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpointsCdc20 associates with the kinase aurora2/AikG2E3 is a dual function ubiquitin ligase required for early embryonic developmentCytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivationCheckpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cellsMad2 transiently associates with an APC/p55Cdc complex during mitosisSpindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochoresRegulation of APC activity by phosphorylation and regulatory factorsTargeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit.Structure of the mitotic checkpoint complexBudding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2The spindle checkpoint of the yeast Saccharomyces cerevisiae requires kinetochore function and maps to the CBF3 domain.MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p.Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylationEmi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteinsCharacterization of a novel kinetochore protein, CENP-HThe anaphase promoting complex/cyclosome: a machine designed to destroyKinetochore "memory" of spindle checkpoint signaling in lysed mitotic cells.Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes.Rapid exchange of mammalian topoisomerase II alpha at kinetochores and chromosome arms in mitosisThe maize homologue of the cell cycle checkpoint protein MAD2 reveals kinetochore substructure and contrasting mitotic and meiotic localization patterns.
P2860
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P2860
Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Mammalian p55CDC mediates asso ...... onset and late mitotic events
@nl
Mammalian p55CDC mediates asso ...... onset and late mitotic events.
@ast
Mammalian p55CDC mediates asso ...... onset and late mitotic events.
@en
type
label
Mammalian p55CDC mediates asso ...... onset and late mitotic events
@nl
Mammalian p55CDC mediates asso ...... onset and late mitotic events.
@ast
Mammalian p55CDC mediates asso ...... onset and late mitotic events.
@en
prefLabel
Mammalian p55CDC mediates asso ...... onset and late mitotic events
@nl
Mammalian p55CDC mediates asso ...... onset and late mitotic events.
@ast
Mammalian p55CDC mediates asso ...... onset and late mitotic events.
@en
P2093
P2860
P3181
P356
P1476
Mammalian p55CDC mediates asso ...... onset and late mitotic events.
@en
P2093
G J Gorbsky
J Weinstein
P2860
P304
P3181
P356
10.1083/JCB.141.6.1393
P407
P577
1998-06-01T00:00:00Z