Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
about
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APCEvidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2betaThe Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregationMAD2B is an inhibitor of the anaphase-promoting complexCrystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpointCrystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1ZW10 links mitotic checkpoint signaling to the structural kinetochore.Identification of two novel components of the human NDC80 kinetochore complexHuman Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signalingDeterminants of conformational dimerization of Mad2 and its inhibition by p31cometNEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signalingDynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpointIdentification of a MAD2-binding protein, CMT2, and its role in mitosis.Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complexMad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochoresLesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiaeCheckpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complexIdentification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulationMicrotubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochoresConformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpointBub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesisMammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpointsLinking kinetochore-microtubule binding to the spindle checkpointCheckpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cellsMicrotubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signalingSpindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activityBub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesisHuman MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochoresAntimitotic drugs in the treatment of cancerComplex Commingling: Nucleoporins and the Spindle Assembly CheckpointKinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint responseA Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration.Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2.Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 DimerBub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins.
P2860
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P2860
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
@ast
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
@en
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
@nl
type
label
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
@ast
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
@en
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
@nl
prefLabel
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
@ast
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
@en
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
@nl
P2093
P2860
P3181
P356
P1476
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
@en
P2093
P2860
P304
P3181
P356
10.1083/JCB.143.2.283
P407
P577
1998-10-19T00:00:00Z