Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint - Test2 - elhamkhani - TriplyDB

Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint

Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint

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Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding Prevention of DNA re-replication in eukaryotic cells What is the functional role of the thalidomide binding protein cereblon?A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery Preventing re-replication of chromosomal DNA.DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1 Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factors Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination Cellular checkpoint mechanisms monitoring proper initiation of DNA replication CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation.USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor CRL4Cdt2: master coordinator of cell cycle progression and genome stability Cul4B regulates neural progenitor cell growth.Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.Selective degradation of splicing factor CAPERα by anticancer sulfonamides.DDB1 maintains genome integrity through regulation of Cdt1 Ultraviolet radiation stress triggers the down-regulation of essential replication factor Mcm10.Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells.Lung tumourigenesis in a conditional Cul4A transgenic mouse model.A protein network-guided screen for cell cycle regulators in Drosophila.The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Cancer models in Caenorhabditis elegans.Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling.

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Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint

http://www.wikidata.org/entity/Q28212584

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2003 nî lūn-bûn

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2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年论文

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Radiation-mediated proteolysis ...... s constitutes a new checkpoint

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Radiation-mediated proteolysis ...... s constitutes a new checkpoint

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Radiation-mediated proteolysis ...... s constitutes a new checkpoint

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Radiation-mediated proteolysis ...... s constitutes a new checkpoint

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Radiation-mediated proteolysis ...... s constitutes a new checkpoint

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Radiation-mediated proteolysis ...... s constitutes a new checkpoint

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Radiation-mediated proteolysis ...... s constitutes a new checkpoint

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Radiation-mediated proteolysis ...... s constitutes a new checkpoint

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Radiation-mediated proteolysis ...... s constitutes a new checkpoint

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Nature Cell Biology

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Radiation-mediated proteolysis ...... s constitutes a new checkpoint

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Damon P Banks

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Hui Zhang

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Ivailo S Mihaylov

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Jianyu Zheng

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Leigh Ann A Higa

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10.1038/NCB1061

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11

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2003-11-01T00:00:00Z

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1014534317

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