The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments - Test2 - elhamkhani - TriplyDB

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

http://www.wikidata.org/entity/Q28576098

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The generation and function of soluble apoE receptors in the CNS SORL1 variants and risk of late-onset Alzheimer's disease Molecular markers of early Parkinson's disease based on gene expression in blood Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1 Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways Mild cognitive impairment: pathology and mechanisms.Retromer Cargos and genes: insights into vesicular transport from inherited human disease Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease Genes associated with Alzheimer's disease: an overview and current status Trafficking regulation of proteins in Alzheimer's disease A fluorescent glycolipid-binding peptide probe traces cholesterol dependent microdomain-derived trafficking pathways Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease SORL1 Gene is Associated with the Conversion from Mild Cognitive Impairment to Alzheimer's Disease Trafficking and proteolytic processing of APP Cargo trafficking in Alzheimer’s disease: the possible role of retromer Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11 Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis Sex moderates the effects of the Sorl1 gene rs2070045 polymorphism on cognitive impairment and disruption of the cingulum integrity in healthy elderly In situ structural characterization of a recombinant protein in native Escherichia coli membranes with solid-state magic-angle-spinning NMR.Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network.Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease Neuronal LR11 expression does not differentiate between clinically-defined Alzheimer's disease and control brains Alzheimer's disease risk genes and mechanisms of disease pathogenesis A membrane proximal helix in the cytosolic domain of the human APP interacting protein LR11/SorLA deforms liposomes.Multivesicular bodies in neurons: distribution, protein content, and trafficking functions.The genetic variation of SORCS1 is associated with late-onset Alzheimer's disease in Chinese Han population.Bacterial expression, purification, and model membrane reconstitution of the transmembrane and cytoplasmic domains of the human APP binding protein LR11/SorLA for NMR studies.BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.

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The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

http://www.wikidata.org/entity/Q28576098

description

2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2006

@ast

im Februar 2006 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2006/02/01)

@sk

vědecký článek publikovaný v roce 2006

@cs

wetenschappelijk artikel (gepubliceerd op 2006/02/01)

@nl

наукова стаття, опублікована в лютому 2006

@uk

مقالة علمية (نشرت في فبراير 2006)

@ar

name

The lipoprotein receptor LR11 ...... ffic in endosomal compartments

@ast

The lipoprotein receptor LR11 ...... ffic in endosomal compartments

@en

The lipoprotein receptor LR11 ...... ffic in endosomal compartments

@nl

type

label

The lipoprotein receptor LR11 ...... ffic in endosomal compartments

@ast

The lipoprotein receptor LR11 ...... ffic in endosomal compartments

@en

The lipoprotein receptor LR11 ...... ffic in endosomal compartments

@nl

prefLabel

The lipoprotein receptor LR11 ...... ffic in endosomal compartments

@ast

The lipoprotein receptor LR11 ...... ffic in endosomal compartments

@en

The lipoprotein receptor LR11 ...... ffic in endosomal compartments

@nl

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JNEUROSCI.4946-05.2006

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Journal of Neuroscience

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The lipoprotein receptor LR11 ...... ffic in endosomal compartments

@en

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Allan I. Levey

http://www.w3.org/2001/XMLSchema#string

James J. Lah

http://www.w3.org/2001/XMLSchema#string

James T. Shoemaker

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Jason J. Fritz

http://www.w3.org/2001/XMLSchema#string

Katrin Offe

http://www.w3.org/2001/XMLSchema#string

Marla Gearing

http://www.w3.org/2001/XMLSchema#string

Sara E. Dodson

http://www.w3.org/2001/XMLSchema#string

P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.

Alzheimer's disease: genes, proteins, and therapy

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1596–1603

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scholarly article

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1578689

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10.1523/JNEUROSCI.4946-05.2006

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5

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26

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2006-02-01T00:00:00Z

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7320947

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16452683

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