Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
about
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomesThe proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break responseThe AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaksUMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathwayBAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sitesThe Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaksK63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damageDNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc fingerRegulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaksMERIT40 facilitates BRCA1 localization and DNA damage repairNBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint controlCdc5L interacts with ATR and is required for the S-phase cell-cycle checkpointATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaksBBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage responseDifferential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylationA ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair networkRing finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damageEpigenetic modifications in double-strand break DNA damage signaling and repairDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsMammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaksMolecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylationUbc13: the Lys63 ubiquitin chain building machineChoreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear ArchitectureRole of Deubiquitinating Enzymes in DNA RepairFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workRepair of strand breaks by homologous recombinationUbiquitination-induced fluorescence complementation (UiFC) for detection of K48 ubiquitin chains in vitro and in live cellsStructural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80Structural basis for role of ring finger protein RNF168 RING domainStructural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domainThe DNA Damage Response: Making It Safe to Play with KnivesHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsA viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responsesMitotic homologous recombination maintains genomic stability and suppresses tumorigenesisDistinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesisA novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phaseThe tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression
P2860
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P2860
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Ubc13/Rnf8 ubiquitin ligases c ...... plex in response to DNA damage
@ast
Ubc13/Rnf8 ubiquitin ligases c ...... plex in response to DNA damage
@en
type
label
Ubc13/Rnf8 ubiquitin ligases c ...... plex in response to DNA damage
@ast
Ubc13/Rnf8 ubiquitin ligases c ...... plex in response to DNA damage
@en
prefLabel
Ubc13/Rnf8 ubiquitin ligases c ...... plex in response to DNA damage
@ast
Ubc13/Rnf8 ubiquitin ligases c ...... plex in response to DNA damage
@en
P2860
P356
P1476
Ubc13/Rnf8 ubiquitin ligases c ...... plex in response to DNA damage
@en
P2093
Stephen J Elledge
P2860
P304
20759-20763
P356
10.1073/PNAS.0710061104
P407
P577
2007-12-05T00:00:00Z