Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes. - Wikidata - wikimedia - TriplyDB

Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.

Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.

http://www.wikidata.org/entity/Q33919648

about

Diversity of CRISPR-Cas immune systems and molecular machines Current and future prospects for CRISPR-based tools in bacteria Breaking bad: R-loops and genome integrity Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes.Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli.STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation Spacer-length DNA intermediates are associated with Cas1 in cells undergoing primed CRISPR adaptation.Target DNA recognition and cleavage by a reconstituted Type I-G CRISPR-Cas immune effector complex.Mechanism of duplex DNA destabilization by RNA-guided Cas9 nuclease during target interrogation.CRISPR/Cas9: From Genome Engineering to Cancer Drug Discovery Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity.Fulfilling the dream of a perfect genome editing tool Cas9 specifies functional viral targets during CRISPR-Cas adaptation.CRISPR-Cas immunity in prokaryotes.The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA.Applications of CRISPR technologies in research and beyond.Applications of CRISPR-Cas9 mediated genome engineering.CRISPR RNA binding and DNA target recognition by purified Cascade complexes from Escherichia coli A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture.The structural biology of CRISPR-Cas systems Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target Extending the range for force calibration in magnetic tweezers A Conserved Structural Chassis for Mounting Versatile CRISPR RNA-Guided Immune Responses.Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements.Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS.Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships.High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding.CRISPR interference and priming varies with individual spacer sequences DNA-binding-domain fusions enhance the targeting range and precision of Cas9.Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome Kinetics of the CRISPR-Cas9 effector complex assembly and the role of 3'-terminal segment of guide RNA.Conformational control of DNA target cleavage by CRISPR-Cas9.Highly efficient primed spacer acquisition from targets destroyed by the Escherichia coli type I-E CRISPR-Cas interfering complex CRISPR-Cas9 nuclear dynamics and target recognition in living cells.The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers

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Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.

http://www.wikidata.org/entity/Q33919648

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Direct observation of R-loop f ...... nd Cascade effector complexes.

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Direct observation of R-loop f ...... nd Cascade effector complexes.

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type

label

Direct observation of R-loop f ...... nd Cascade effector complexes.

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Direct observation of R-loop f ...... nd Cascade effector complexes.

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prefLabel

Direct observation of R-loop f ...... nd Cascade effector complexes.

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Direct observation of R-loop f ...... nd Cascade effector complexes.

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PNAS.1402597111

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Proceedings of the National Academy of Sciences of the United States of America

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Direct observation of R-loop f ...... and Cascade effector complexes

@en

P2093

Giedrius Gasiunas

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Patrizia Pschera

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Ralf Seidel

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Tautvydas Karvelis

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Tomas Sinkunas

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Virginijus Siksnys

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P2860

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

Cas9 as a versatile tool for engineering biology

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes

Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity

Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

Small CRISPR RNAs guide antiviral defense in prokaryotes

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

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27

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111

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Mark D. Szczelkun

Maria S Tikhomirova

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2014-05-27T00:00:00Z

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264635289

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24912165

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4103346

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