Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
about
RAG1 core and V(D)J recombination signal sequences were derived from Transib transposonsRING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitinationThe RAG1 N-terminal domain is an E3 ubiquitin ligaseVprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelityRch1, a protein that specifically interacts with the RAG-1 recombination-activating proteinRAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2High precision NMR structure and function of the RING-H2 finger domain of EL5, a rice protein whose expression is increased upon exposure to pathogen-derived oligosaccharidesMechanistic constraints on diversity in human V(D)J recombinationMolluscan mobile elements similar to the vertebrate Recombination-Activating GenesExpression and V(D)J recombination activity of mutated RAG-1 proteinsAutoubiquitylation of the V(D)J recombinase protein RAG1Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinaseA WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactionsCrystal structure of the V(D)J recombinase RAG1-RAG2Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingSelf-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.The origins of the Rag genes--from transposition to V(D)J recombination.Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination.Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficienciesRetroviral expression in embryonic stem cells and hematopoietic stem cells.Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic miceThe RAG proteins in V(D)J recombination: more than just a nuclease.Deletion of the RAG2 C terminus leads to impaired lymphoid development in miceMobilization of RAG-generated signal ends by transposition and insertion in vivoThe C-terminal portion of RAG2 protects against transposition in vitroA Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblastsOverlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end ComplexesIn vitro V(D)J recombination: signal joint formation.Recruitment of RAG1 and RAG2 to Chromatinized DNA during V(D)J Recombination.A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinaseImpaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.Pendulin, a Drosophila protein with cell cycle-dependent nuclear localization, is required for normal cell proliferation.rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent.A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.
P2860
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P2860
Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
@ast
Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
@en
type
label
Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
@ast
Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
@en
prefLabel
Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
@ast
Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
@en
P2093
P2860
P356
P1476
Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
@en
P2093
D Baltimore
D P Silver
E Spanopoulou
R C Mulligan
P2860
P304
P356
10.1073/PNAS.90.13.6100
P407
P577
1993-07-01T00:00:00Z