Radiosensitivity in ataxia-telangiectasia: a new explanation.
about
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesisSMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointInteraction between human MCM7 and Rad17 proteins is required for replication checkpoint signalingCdc5L interacts with ATR and is required for the S-phase cell-cycle checkpointA human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control genePhosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint responseReplication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexesActivation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firingHRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control genePhosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damageThe product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitorHuman Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpointMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionHuman Claspin works with BRCA1 to both positively and negatively regulate cell proliferationMultiple roles of ATM in monitoring and maintaining DNA integrityInduction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase CThe human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacementChromatin perturbations during the DNA damage response in higher eukaryotesRadio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinicCrystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA RepairA novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription.Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathwayEpithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout miceSuppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathwaysChecking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressorRegulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpointsATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient backgroundThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlThe yeast Xrs2 complex functions in S phase checkpoint regulationRegulating mammalian checkpoints through Cdc25 inactivation.ATM-dependent MiR-335 targets CtIP and modulates the DNA damage responseInvolvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiationRB-dependent S-phase response to DNA damageATR: an essential regulator of genome integrityTitanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts.Radiation down-regulates replication origin activity throughout the S phase in mammalian cells.Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damage.Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesisNegative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1.
P2860
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P2860
Radiosensitivity in ataxia-telangiectasia: a new explanation.
description
1980 nî lūn-bûn
@nan
1980年の論文
@ja
1980年学术文章
@wuu
1980年学术文章
@zh-cn
1980年学术文章
@zh-hans
1980年学术文章
@zh-my
1980年学术文章
@zh-sg
1980年學術文章
@yue
1980年學術文章
@zh
1980年學術文章
@zh-hant
name
Radiosensitivity in ataxia-telangiectasia: a new explanation.
@ast
Radiosensitivity in ataxia-telangiectasia: a new explanation.
@en
type
label
Radiosensitivity in ataxia-telangiectasia: a new explanation.
@ast
Radiosensitivity in ataxia-telangiectasia: a new explanation.
@en
prefLabel
Radiosensitivity in ataxia-telangiectasia: a new explanation.
@ast
Radiosensitivity in ataxia-telangiectasia: a new explanation.
@en
P2860
P356
P1476
Radiosensitivity in ataxia-telangiectasia: a new explanation.
@en
P2093
P2860
P304
P356
10.1073/PNAS.77.12.7315
P407
P577
1980-12-01T00:00:00Z