A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3.
about
Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticlesSrc family kinase-mediated and Erk-mediated thromboxane A2 generation are essential for VWF/GPIb-induced fibrinogen receptor activation in human plateletsSequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3Glycoprotein Ib cross-linking/ligation on echicetin-coated surfaces or echicetin-IgMkappa in stirred suspension activates platelets by cytoskeleton modulated calcium releaseP2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activationThrombin and vascular inflammationAn important role of the SRC family kinase Lyn in stimulating platelet granule secretionRGT, a synthetic peptide corresponding to the integrin beta 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin alpha IIb beta 3 with Src kinase.Integrated Biophysical and Biochemical Signals Augment Megakaryopoiesis and Thrombopoiesis in a Three-Dimensional Rotary Culture System.The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function.Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling.Metastasis of tumor cells is enhanced by downregulation of Bit1.Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta).Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation.Signaling during platelet adhesion and activationEchicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregationNucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis.Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation.Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo.Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and ThrombosisA molecular switch that controls cell spreading and retraction.Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.Timosaponin AIII induces antiplatelet and antithrombotic activity via Gq-mediated signaling by the thromboxane A2 receptorPlatelet GPIb-IX-V-dependent signaling.Integrin activation by talin.Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signalingPlatelet-derived HMGB1 is a critical mediator of thrombosis.The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activationSrc family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis.Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathwayp21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear.Antiplatelet Activity of Morus alba Leaves Extract, Mediated via Inhibiting Granule Secretion and Blocking the Phosphorylation of Extracellular-Signal-Regulated Kinase and Akt.P2Y12 receptor: platelet thrombus formation and medical interventions.New Concepts and Mechanisms of Platelet Activation Signaling.Activation of integrin alpha IIb beta 3 in the glycoprotein Ib-high population of a megakaryocytic cell line, CMK, by inside-out signaling.Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3.Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation.Stressed platelets ASK1 for a MAPK.Ghrelin protects human umbilical vein endothelial cells against advanced glycation end products-induced apoptosis via NO/cGMP signaling.
P2860
Q26830366-29E0B46F-579E-4218-B53F-AAFBE656C494Q28183746-F2943797-0254-4E42-81EE-0DBE293C26F9Q28192455-A26D4445-3FB1-4B6D-A6C8-C17D76E1B6B4Q28193834-36B2C3B3-944E-4E88-8241-D3CBB19C38F9Q28194880-D0EF7287-EB31-48BF-83FB-78B01BF5ECC8Q28246124-801C5088-FA9B-4FC0-8635-4BBA95F76ED8Q28588935-58084300-BA13-4EB3-AF6F-1CED336C5C69Q30157707-20D098D0-F25E-4887-AE91-DC1EAB7F083AQ30702462-5B6AB24A-965B-49A1-8914-AA7E5BED2D52Q33519081-D93FF693-33F8-4463-887D-1F752CF8FAF8Q33838840-1587A6AE-D21C-4F82-8075-3A5694B933F4Q34008985-376203A4-B644-460C-9757-9AC6E55C8C8CQ34152904-2946B4AE-2615-498E-A702-AF3BBE2034EFQ34448738-ED55E8CD-6FDF-44DB-9B9F-7A0836923DEFQ34895427-D65429E1-085E-436F-9F84-F488EBE128F7Q35140258-570A115F-D4B1-40B2-883F-33D0C87A7DA3Q35246390-FCCCD436-D70E-4624-BC32-1DABC8B3204AQ35266258-C787BD41-4493-4EE8-BDBA-3B2D680EC557Q35849237-8CF32F21-E1AE-4561-8768-DEECD257544FQ35961805-D924707F-CAD4-46C5-BC8D-BC249448254FQ36119672-E29DDDF4-1C29-48AB-A034-F4807C7BB2EDQ36151315-B8A02462-3AF8-4F05-8722-CE9D8953ECE9Q36217246-86693B38-A1AF-4786-9A7B-BE77C809C471Q36230867-2C903315-912E-4515-8414-B277C0175BCEQ36230871-2DD28238-3421-4593-BD9B-C252F0408E47Q36323239-6A0BB56A-A1F6-4333-BC85-75859AE41FEFQ36335907-96698E33-4C43-4B81-887D-4C4DBA0FA31BQ36384795-5A80B2BF-B65E-4743-8B8F-5DAD56A8F22AQ36835135-066F1EB7-2657-4389-9A8D-13A6B275A5C6Q36889753-B11E96A7-3310-4322-BAD6-5DFACD4C09BEQ37071121-5E8A372C-ABE1-4698-929F-5793C54D53E7Q37609187-0C018E6E-33AC-45DF-A2D5-CB51E4A8A24FQ37631402-95C45191-FD1F-49FB-9A3F-04066F3035A2Q38051192-07D37778-8092-4BCF-B456-713649ED3317Q39147112-7CCD8FED-8EC5-4AF2-BACE-CB5A8EDD0D1EQ40600278-CC82B792-858E-4A01-A6D8-8F86D5C3AAB6Q40686073-9C2E283C-AA39-43B9-9A7D-51C457B8A76BQ40694330-7EB92CBA-07DB-4B88-B22E-B6058692586EQ41873590-887C3526-AA27-4C2F-9D6F-D523D6552308Q41992363-127FA2E6-E526-415A-A380-B99CF07D8F9D
P2860
A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
A mitogen-activated protein ki ...... telet integrin alpha IIbbeta3.
@en
A mitogen-activated protein ki ...... telet integrin alpha IIbbeta3.
@nl
type
label
A mitogen-activated protein ki ...... telet integrin alpha IIbbeta3.
@en
A mitogen-activated protein ki ...... telet integrin alpha IIbbeta3.
@nl
prefLabel
A mitogen-activated protein ki ...... telet integrin alpha IIbbeta3.
@en
A mitogen-activated protein ki ...... telet integrin alpha IIbbeta3.
@nl
P2093
P2860
P356
P1476
A mitogen-activated protein ki ...... telet integrin alpha IIbbeta3.
@en
P2093
P2860
P304
42226-42232
P356
10.1074/JBC.M106129200
P407
P577
2001-08-24T00:00:00Z