BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
about
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαThe schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapseAssembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesisTRIM32 is an E3 ubiquitin ligase for dysbindinBLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organellesBLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organellesThe dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowthMelanosomes--dark organelles enlighten endosomal membrane transportBLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery.Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1.The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3.SNAREs in the maturation and function of LROsThe BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organellesHermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampusBLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomesPhosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome trafficRole of dysbindin in dopamine receptor trafficking and cortical GABA functionRoles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesiclesDysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade.SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis.BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriersA data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1).Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner.Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes.Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency.Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes.AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor intC. elegans BLOC-1 functions in trafficking to lysosome-related gut granules.Myosin vc interacts with Rab32 and Rab38 proteins and works in the biogenesis and secretion of melanosomesMeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.Palmitoylation controls the catalytic activity and subcellular distribution of phosphatidylinositol 4-kinase II{alpha}Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses.Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models.The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.Mechanisms of protein delivery to melanosomes in pigment cells.
P2860
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P2860
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
description
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
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im September 2006 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2006/09/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/09/01)
@nl
наукова стаття, опублікована у вересні 2006
@uk
مقالة علمية (نشرت في سبتمبر 2006)
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name
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
@ast
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
@en
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
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type
label
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
@ast
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
@en
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
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prefLabel
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
@ast
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
@en
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
@nl
P2093
P2860
P3181
P356
P1476
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes
@en
P2093
A. A. Peden
B. H. Wainer
E. C. Dell'Angelica
G. Salazar
J. M. Falcon-Perez
K. A. Newell-Litwa
M. L. Styers
M. M. Doucette
P2860
P304
P3181
P356
10.1091/MBC.E06-02-0103
P577
2006-09-01T00:00:00Z