The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. - Test2 - elhamkhani - TriplyDB

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.

http://www.wikidata.org/entity/Q36898085

about

CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription Examination of the expanding pathways for the regulation of p21 expression and activity.Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B The p53 circuit board Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis Gain of function in CDKN1C A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle Genetic abolishment of hepatocyte proliferation activates hepatic stem cells CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity 14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNA CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation CRL4Cdt2: master coordinator of cell cycle progression and genome stability p21 in cancer: intricate networks and multiple activities DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.The Control of Arabidopsis thaliana Growth by Cell Proliferation and Endoreplication Requires the F-Box Protein FBL17.CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer.Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells.The CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans development.Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.Lung tumourigenesis in a conditional Cul4A transgenic mouse model.PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?Thymine DNA glycosylase is a CRL4Cdt2 substrate.The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.DNA replication, RNAi and epigenetic inheritance.

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P2860

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.

http://www.wikidata.org/entity/Q36898085

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

The CRL4Cdt2 ubiquitin ligase ...... control replication licensing.

@en

type

label

The CRL4Cdt2 ubiquitin ligase ...... control replication licensing.

@en

prefLabel

The CRL4Cdt2 ubiquitin ligase ...... control replication licensing.

@en

P1433

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P2860

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P1433

Genes & Development

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The CRL4Cdt2 ubiquitin ligase ...... control replication licensing.

@en

P2093

Edward T Kipreos

http://www.w3.org/2001/XMLSchema#string

Natalia G Starostina

http://www.w3.org/2001/XMLSchema#string

Youngjo Kim

http://www.w3.org/2001/XMLSchema#string

P2860

Cullin-RING ubiquitin ligases: global regulation and activation cycles

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint

Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1

Loss of Geminin induces rereplication in the presence of functional p53

Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans

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2507-2519

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scholarly article

P356

10.1101/GAD.1703708

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P433

18

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22

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P577

2008-09-01T00:00:00Z

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23258110

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18794348

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2546690

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