A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production.
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Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretaseDifferential release of β-amyloid from dendrite- versus axon-targeted APP.A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPaseFunction, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Dysregulation of protein trafficking in neurodegeneration.Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.Synaptotagmins interact with APP and promote Aβ generation.Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampusAmyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neuronsVisualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tractsFunctions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3).Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking.The endosomal neuronal proteins Nsg1/NEEP21 and Nsg2/P19 are itinerant, not resident proteins of dendritic endosomes.Genome-wide RNAi screen reveals a role for multipass membrane proteins in endosome-to-golgi retrieval.Derailed intraneuronal signalling drives pathogenesis in sporadic and familial Alzheimer's disease.Molecular neurodegeneration: basic biology and disease pathways.Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production.The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis.Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1.Alzheimer disease: modeling an Aβ-centered biological network.Bin1 and CD2AP polarise the endocytic generation of beta-amyloid.BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
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A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A function for EHD family prot ...... eimer's disease Aβ production.
@en
A function for EHD family prot ...... eimer's disease Aβ production.
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type
label
A function for EHD family prot ...... eimer's disease Aβ production.
@en
A function for EHD family prot ...... eimer's disease Aβ production.
@nl
prefLabel
A function for EHD family prot ...... eimer's disease Aβ production.
@en
A function for EHD family prot ...... eimer's disease Aβ production.
@nl
P2093
P2860
P1433
P1476
A function for EHD family prot ...... eimer's disease Aβ production.
@en
P2093
Angèle T Parent
Aureliane Elie
Celia G Fernandez
Gopal Thinakaran
Hamid Band
Jelita Roseman
Kulandaivelu S Vetrivel
Manju George
Margaret Lefkow
Robert Vassar
P2860
P304
P356
10.1016/J.CELREP.2013.12.006
P577
2013-12-01T00:00:00Z