Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.
about
The RAG1 N-terminal domain is an E3 ubiquitin ligaseRecombination-activating gene proteins: more regulation, pleaseThe taming of a transposon: V(D)J recombination and the immune systemAutoubiquitylation of the V(D)J recombinase protein RAG1A PHD finger motif in the C terminus of RAG2 modulates recombination activityAdapting to a changing world: RAG genomics and evolutionElucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingIntermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.Postcleavage sequence specificity in V(D)J recombination.Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.The RAG proteins in V(D)J recombination: more than just a nuclease.Deletion of the RAG2 C terminus leads to impaired lymphoid development in miceMobilization of RAG-generated signal ends by transposition and insertion in vivoAutoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombinationCoupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.The C-terminal portion of RAG2 protects against transposition in vitroRegulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.The RAG2 C terminus suppresses genomic instability and lymphomagenesis.Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.The bounty of RAGs: recombination signal complexes and reaction outcomes.V(D)J recombination: how to tame a transposase.New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.Role of RAG1 autoubiquitination in V(D)J recombination.Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.RAG-dependent primary immunodeficiencies.Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination.A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.The roles of the RAG1 and RAG2 "non-core" regions in V(D)J recombination and lymphocyte development.The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage.Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex.Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition but not hybrid joint formation or disintegration.New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination.The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends.Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins.
P2860
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P2860
Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Roles of the "dispensable" portions of RAG-1 and RAG-2 in V
@nl
Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.
@en
type
label
Roles of the "dispensable" portions of RAG-1 and RAG-2 in V
@nl
Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.
@en
prefLabel
Roles of the "dispensable" portions of RAG-1 and RAG-2 in V
@nl
Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.
@en
P2093
P2860
P356
P1476
Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.
@en
P2093
P2860
P304
P356
10.1128/MCB.19.4.3010
P407
P577
1999-04-01T00:00:00Z